胰腺癌早期检测协会

来自以下人群的个人在任何参与地点参加临床评估和PDAC风险评估，可以被邀请参与pre数据库: Cohort 1 没有PDAC病史的个人符合以下任何标准:

• 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; age 50+ or ≤10 years younger than earliest PDAC in family at time of diagnosis.
• 2 affected first degree relatives with PDAC; age 50+ or 10 years younger than earliest PDAC in family
• BRCA1, BRCA2, PALB2, ATM, MLH1, MSH2, MSH6, PMS2, EPCAM pathogenic or likely pathogenic variant AND 1 first or second degree relative with PDAC; age 50+ or 10 years younger than earliest PDAC in family
• Familial Atypical Moles and Malignant Melanoma (FAMMM) with pathogenic or likely pathogenic CDKN2A variant; age 40+
• Peutz-Jegher syndrome with STK11 pathogenic or likely pathogenic variant; age 35+
• Hereditary pancreatitis with PRSS1 pathogenic or likely pathogenic variant and history of pancreatitis; age 40+ Cohort 2 没有PDAC病史的个人符合以下任何标准:
• ATM, BRCA1, BRCA2, 或PALB2致病性或可能致病性变异，与家族史无关, age 50+
• 同侧有2个以上患有PDAC的亲属, 任何程度的关系, not meeting other criteria above; age 50+ or 10 years younger than earliest PDAC in family
• 1 first degree relative with PDAC ≤ age 45; age up to 10 years younger than PDAC diagnosis in family member 第3组除年龄外，符合第1组或第2组标准的个人.e. 太年轻而不能进入第1组或第2组) 队列4:没有PDAC病史但不符合1-3项标准的患者前来评估, 6, 或者囊肿队列. 队列5:没有PDAC病史的个体，如果不在参与站点进行胰腺监测，可能会被邀请加入PRECEDE数据库并捐赠生物样本.g. 血液，唾液和/或口腔拭子)用于发现研究. 这可能包括队列1-4,6和囊肿队列中个体的亲属. Cohort 6 有PDAC病史且符合以下任何条件的个人:
• 家族史包括至少一个一级亲属与PDAC, 或2名有PDAC的亲属，且彼此有一级血缘关系
• 个人或家族史的致病性或可能致病性种系变异的ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2,PMS2, PRSS1, STK11
• 诊断年龄≤45岁 囊肿队列:有胰腺囊性肿瘤病史的个体，不符合队列1-3或6的任何标准(没有已知的PDAC家族史), 没有已知的与PDAC风险相关的致病种系变异)

• 不符合上述条件的个人.